You should know the #1 reason why many people fail to grow taller despite their substantial efforts.

The #1 reason why many people fail to grow taller is because they do not have a scientific way to naturally increase their growth hormone level. Growth hormone is the most important factor in controlling your bone growth because it is the only hormone that stimulates the growth of cartilage cells at the end of your bones (which is solely responsible for the vertical growth of your bones). Some people think they can increase their growth hormone level just by doing exercises like stretching and jumping -- WRONG! The production of growth hormone is primarily controlled by a mechanism called the Negative Feedback Circuit.

Feedback circuits are at the root of most control mechanisms in physiology, and are particularly prominent in the endocrine system. Instances of positive feedback certainly occur, but negative feedback is much more common. Negative feedback is seen when the output of a pathway inhibits input to the pathway. The heating system in your home is a simple Negative Feedback Circuit. When the furnace produces enough heat to elevate temperature above the set point of the thermostat, the thermostat is triggered and shuts off the furnace (heat is feeding back negatively on the source of heat). When temperature drops back below the set point, negative feedback is gone, and the furnace comes back on.

In your case, the Negative Feedback Circuit is used extensively to regulate secretion of growth hormone. The release of growth hormone by the pituitary gland is actually controlled by the other two hormones:

* GHRH (Growth hormone-releasing hormone) is a peptide that stimulates the secretion of growth hormone in response to the low blood concentration of growth hormone and other stimulatory factors such as a high blood concentration of glucose.

SS (Somatostatin) is a peptide that inhibits the secretion of growth hormone in response to GHRH and other stimulatory factors such as a low blood concentration of glucose.

The Negative Feedback Circuit uses these two hormones to control the secretion of growth hormone. The basic mechanisms for the negative feedback control in this system are:

1. GHRH-secreting neurons in the brain detect the low blood concentration of growth hormone, and in response these neurons secrete GHRH, which is then carried directly to the pituitary gland. Once it enters the pituitary gland, GHRHstimulates the activities of somatotrophs (cells which secrete growth hormone) and these cells start to release growth hormone.

2. Growth hormone binds to receptors on targeted cells in the body, promoting carbohydrate metabolism, protein synthesis, and fat mobilization. Growth hormone also stimulates the liver and other tissues to secrete IGF-1(Insulin-like Growth Factor-1). IGF-1 in turn acts on its target cells, i.e., chondrocytes (cartilage cells) andmyoblasts (precursors of muscle cells) to stimulate muscle and bone growth.

3. Increasing growth hormone level soon negatively feedback to inhibit GHRH secretion. When blood concentration of growth hormone increases above a certain threshold, GHRH-secreting neurons in the brain are inhibited and stop secreting GHRH, while SS-secreting neurons are stimulated and start secreting SS, which is then carried directly to the pituitary gland. Once it enters the pituitary gland, SSinhibits the activities of somatotrophs (cells which secrete growth hormone) and these cells stop releasing growth hormone. Growth hormone's byproduct - IGF-1 also triggers the Negative Feedback Circuit. Increased growth hormone level stimulates the liver to secrete IGF-1. A high blood level of IGF-1 not only stimulates the release of SS, but also directly suppresses the somatotrophs in the pituitary gland. The combined effect is the immediate turn-off of growth hormone secretion.

4. As growth hormone levels decrease below the threshold, negative feedback is relieved, GHRH secretion starts again, leading to growth hormone secretion... and the cycle restarts again.

Integration of all the factors that affect growth hormone synthesis and secretion lead to a pulsatile pattern of release. The natural concentration of growth hormone in the blood is very low, because usually the body only secretes growth hormone up to a level to maintain homeostasis and once a steady state is achieved growth hormone secretion is stopped by the Negative Feedback Circuit. Therefore, the only effective way to increase the secretion of growth hormone is to minimize the effect of the Negative Feedback Circuit by creating a natural Positive Feedback Circuit.

Positive feedback is seen when the output of a pathway stimulates input to the pathway. An example of positive feedback is the phenomenon of autocatalysis, which occurs in some digestive enzymes such as pepsin. Pepsin is a protein-digesting enzyme that works in the stomach. However, the stomach does not secrete pepsin; it secretes an inactive form, called pepsinogen. When one pepsinogen molecule becomes activated, it helps to activate other pepsinogensnearby, which in turn can activate others. In this way, the number of active pepsin molecules can increase rapidly, by using positive feedback.

In your case, you need a Positive Feedback Circuit that minimizes the effect of your body's Negative Feedback Circuit and maximizes your pituitary gland's secretion of growth hormone. Here is where our great Kimi device comes to serve you: the application of Kimi will create a natural Positive Feedback Circuit by stimulating the activities of your adrenal gland, pancreas, and liver. 
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